Unit content
Voltage-gated ion channels and electrical excitability
A voltage-gated ion channel is an ion channel whose probability of being open depends on the membrane potential.
This creates a feedback link:
membrane voltage changes
↓
channel gating changes
↓
ion conductance changes
↓
ion flow changes membrane voltage
Because voltage controls channels and channels control voltage, excitable membranes can produce rapid regenerative responses.
Depolarization and hyperpolarization
A membrane depolarizes when its voltage becomes less negative or more positive. It hyperpolarizes when its voltage becomes more negative.
Opening a selective ion channel tends to move the membrane potential toward that ion's equilibrium potential. Thus opening a Na$^+$-selective channel in a cell whose $E_{Na}$ is strongly positive usually depolarizes the membrane, while opening a K$^+$-selective channel when $E_K$ is more negative usually drives the voltage in the opposite direction.
Activation and inactivation are different
Many voltage-gated channels do not simply switch between permanently closed and permanently open states.
A channel can undergo activation, entering a conducting state after a voltage change, and later inactivation, entering a nonconducting state even while the activating voltage remains.
For a common voltage-gated Na$^+$ channel pattern:
resting closed
↓ depolarization
open
↓ delayed inactivation
inactivated
↓ repolarization and recovery
resting closed
Voltage-gated K$^+$ channels often activate more slowly and help return the membrane toward negative voltages.
Positive and negative feedback
If depolarization opens Na$^+$ channels and Na$^+$ entry causes further depolarization, the result is positive feedback.
If delayed K$^+$ channel opening drives the voltage back toward $E_K$, that contributes a restoring influence.
Electrical excitability therefore does not come from voltage alone. It emerges from the voltage dependence, ion selectivity and timing of channel gating.